Journal article
Hyporesponsiveness to re-challenge dose following pneumococcal polysaccharide vaccine at 12 months of age, a randomized controlled trial
FM Russell, JR Carapetis, A Balloch, PV Licciardi, AWJ Jenney, L Tikoduadua, L Waqatakirewa, J Pryor, J Nelson, GB Byrnes, YB Cheung, MLK Tang, EK Mulholland
Vaccine | Published : 2010
Abstract
Background: To evaluate the immunological impact of the 23-valent pneumococcal polysaccharide vaccine (23vPPS) at 12 months, for children who have received zero to three infant doses of seven-valent pneumococcal conjugate vaccine (PCV), on responses to a subsequent exposure to a small dose of 23vPPS (mPPS). Methods: Five hundred and fifty-two Fijian infants were stratified by ethnicity and randomized into eight groups to receive zero, one, two, or three PCV doses at 14 weeks, six and 14 weeks, or six, ten, and 14 weeks. Within each group, half received 23vPPS at 12 months and all received mPPS at 17 months. Sera were taken prior and one month post-mPPS. Findings: By 17 months, geometric mean..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
The authors wish to sincerely thank all the FIPP staff and families participating in the study, and the many other people who contributed to the study including: Amanda O'Brien, Kathryn Bright, Samantha Colquhoun, Amy Bin Chen, Timothy Gemetzis, Amy Auge, Katherine Gilbert, Evan Willis, Philip Greenwood, Beth Temple, Vanessa Johnston, Loretta Thorn, Porter Anderson, Brian Greenwood, George Siber, David Klein, Elizabeth Horigan, and Farukh Khambaty. The authors wish to thank the DSMB members. Pneumovax (TM) was kindly donated by CSL Biotherapies, Australia. The co-administered Tritanrix (TM)-HepB (TM) and Hiberix (TM) vaccines were kindly donated by GlaxoSmithKline. Conflicts of interest. MLT has been a consultant/advisor for Wyeth. The other authors declared no conflicts of Interest. Funding: Funding was provided by the U.S. NIAID and the Australian National Health and Medical Research Council. Trials registration. Clinical Trial Registry, National Library of Medicine, USA. Clinical trial number: NCT00170612.